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Search for effective chemical quenching to arrest molecular assembly and directly monitor DNA nanostructure formation

https://doi.org/10.1039/c6nr08433h

Majikes, J. M.; Nash, J. A.; LaBean, T. H. (January 2017, Nanoscale)

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An easy-to-prepare mini-scaffold for DNA origami

https://doi.org/10.1039/C5NR04921K

Brown, S.; Majikes, J.; Martínez, A.; Girón, T. M.; Fennell, H.; Samano, E. C.; LaBean, T. H. (January 2015, Nanoscale)

The DNA origami strategy for assembling designed supramolecular complexes requires ssDNA as a scaffold strand. A system is described that was designed approximately one third the length of the M13 bacteriophage genome for ease of ssDNA production. Folding of the 2404-base ssDNA scaffold into a variety of origami shapes with high assembly yields is demonstrated.
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Electronically addressable nanomechanical switching of i-motif DNA origami assembled on basal plane HOPG

https://doi.org/10.1039/c5cc04678e

Campos, R.; Zhang, S.; Majikes, J. M.; Ferraz, L. C.; LaBean, T. H.; Dong, M. D.; Ferapontova, E. E. (January 2015, Chemical Communications)

Here, a pH-induced nanomechanical switching of i-motif structures incorporated into DNA origami bound onto cysteamine-modified basal plane HOPG was electronically addressed, demonstrating for the first time the electrochemical read-out of the nanomechanics of DNA origami. This paves the way for construction of electrode-integrated bioelectronic nanodevices exploiting DNA origami patterns on conductive supports.
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